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    Tadalafil (40 mg once per day) Inform patients that tadalafil is also marketed as CIALIS for erectile dysfunction adcirca ® tadalafil tablets.


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    Not studied for multiple attempts per dose.†In clinical trials, CIALIS 20 mg for use as needed was shown to improve, up to 36 hours after dosing, the ability of men with ED to have a single successful intercourse attempt.‡In clinical trials, CIALIS for use as needed started to work in 30 minutes.

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    Structured Product Labeling (SPL) resources for industry professionals.
    These highlights do not include all the information needed to use ADCIRCA safely and effectively.
    Dividing the dose (40 mg) over the course of the day is not recommended.
    Use with ritonavir requires dosage adjustments.
    Cardiovascular effects: Carefully consider whether patients with certain underlying conditions (e.
    ADCIRCA. Not recommended in patients with pulmonary veno-occlusive disease.
    Concomitant alpha-blockers or alcohol: Note additive blood pressure-lowering effects.

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    Use with Ritonavir: Requires dosage adjustment.
    Potent Inducers of CYP3A: Avoid use of ADCIRCA in patients chronically taking potent inducers of CYP3A (e.
    Hearing impairment: Advise patients to seek immediate medical attention if sudden decrease or loss of hearing occurs.
    Concomitant PDE5 inhibitors: Avoid use with CIALIS or other PDE5 inhibitors.
    Prolonged erection: Advise patients to seek emergency treatment if an erection lasts 4 hours.
    Mild or moderate: Start with 20 mg once daily.
    Mild or moderate: Consider starting dose of 20 mg once daily.
    Sections or subsections omitted from the full prescribing information are not listed.
    Mild (creatinine clearance 51 to 80 mL/min) or moderate (creatinine clearance 31 to 50 mL/min): Start dosing at 20 mg once daily.
    Increase to 40 mg once daily based on individual tolerability.

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